Primary amine-metal Lewis acid bifunctional catalysts based on a simple bidentate ligand: direct asymmetric aldol reaction.
نویسندگان
چکیده
A novel class of primary amine-metal Lewis acid bifunctional catalysts based on a bidentate ligand was developed. These catalysts were highly efficient in catalyzing the direct asymmetric aldol reactions of ketones offering excellent stereoselectivity. The aldol reactions required a low catalyst loading (2.5 mol%), and were water compatible.
منابع مشابه
Primary amine-metal Lewis acid bifunctional catalysts: the application to asymmetric direct aldol reactions.
The first example of metal Lewis acid-primary amine bifunctional cooperative catalyst derived from primary amino acids was developed, and it was found to catalyze aldol reactions of cyclic ketones highly efficiently with very good to excellent stereoselectivities.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 1 شماره
صفحات -
تاریخ انتشار 2011